![]() As a result, it is important to administer drug A to the target every 5 hours to ensure its effective therapeutic range.Īnother important application of half life in pharmacokinetics is that half-life tells how tightly drugs bind to each ligands before it is undergoing decay (\(k_s\)). The effectiveness factor is defined as the ratio of the reaction rate actually observed to the reaction rate calculated if the surface reactant concentration persisted throughout the interior of the particle, i.e., no reactant concentration gradient within the particle. To ensure its maximal effect of the drug in the target, the administration will be monitored so that the minimum serum concentration will never go lower than 15 mg/L and the maximum serum concentration will never exceed 30 mg/L. Once the drug is metabolized in the target, its concentration will decrease over time. The therapeutic range of drug A is 15-30 mg/L. Equation 14.4.2 has the form of the algebraic equation for a straight line, y mx + b, with y A, mx kt, and b A0. where A0 is the initial concentration of reactant A. The Weisz Prater criterion has been derived by analyzing a model catalyst with zero and positive reaction orders and by using the general assumption for. \): PharmacokineticsĪ following example is given below to illustrate the role of half life in pharmacokinetics to determine the drugs dosage interval. The integrated rate law for a zeroth-order reaction also produces a straight line and has the general form. ![]()
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